ABSTRACT
We aimed to establish reference ranges for USCOM parameters in preterm infants, determine factors that affect cardiac output, and evaluate the measurement repeatability. This retro-prospective study was performed at Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. We included infants below 32 weeks of gestational age (GA) and/or 1500 g of birth weight (BW). We excluded infants with congenital heart diseases or hemodynamic instability. Measurements were performed at 3 ± 1, 7 ± 2, and 14 ± 2 postnatal days. We analyzed 204 measurements from 92 patients (median GA = 30.57 weeks, BW = 1360 g). The mean (SD) cardiac output (CO) was 278 (55) ml/min/kg, cardiac index (CI) was 3.1 (0.5) L/min/m2, and systemic vascular resistance (SVRI) was 1292 (294) d*s*cm-5/m2. CO presented a negative correlation with postmenstrual age (PMA), while SVRI presented a positive correlation with PMA. The repeatability coefficient was 31 ml/kg/min (12%). Conclusion: This is the first study describing reference values for USCOM parameters in hemodynamically stable preterm infants and factors affecting their variability. Further studies to investigate the usefulness of USCOM for the longitudinal assessment of patients at risk for cardiovascular instability or monitoring the response to therapies are warranted. What is Known: ⢠The ultrasonic cardiac output monitoring (USCOM) has been widely used on adult and pediatric patients and reference ranges for cardiac output (CO) by USCOM have been established in term infants. What is New: ⢠We established reference values for USCOM parameters in very preterm and very-low-birth-weight infants; the reference ranges for CO by USCOM in the study population were 198-405 ml/kg/min. ⢠CO normalized by body weight presented a significant negative correlation with postmenstrual age (PMA); systemic vascular resistance index presented a significant positive correlation with PMA.
Subject(s)
Cardiac Output , Infant, Premature , Humans , Infant, Newborn , Cardiac Output/physiology , Male , Female , Reference Values , Prospective Studies , Retrospective Studies , Hemodynamics/physiology , Reproducibility of Results , Gestational Age , Monitoring, Physiologic/methods , Vascular Resistance/physiologySubject(s)
Cytomegalovirus Infections , Hypertension, Pulmonary , Infant, Newborn , Humans , Hypertension, Pulmonary/drug therapy , Hypertension, Pulmonary/etiology , Valacyclovir/therapeutic use , Hyperplasia , Cytomegalovirus Infections/complications , Cytomegalovirus Infections/drug therapy , Lung/diagnostic imaging , Microvessels , Antiviral Agents/therapeutic useSubject(s)
Cytomegalovirus Infections , Pregnancy Complications, Infectious , Pregnancy , Infant, Newborn , Female , Humans , Valacyclovir/therapeutic use , Amniocentesis , Antiviral Agents/therapeutic use , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/drug therapy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/drug therapy , Infectious Disease Transmission, Vertical/prevention & controlABSTRACT
Italy is one of the most exposed countries worldwide to COVID-19, and Lombardy is the most affected region in Italy. In this context, Fondazione IRCCS Policlinico San Matteo in Pavia, one of the largest University hospitals in the region, has been involved in the management of the outbreak since its inception. Immediately after the communication of the first Italian COVID-19+ patient, the Pediatric Unit has been completely reorganized to face the approaching outbreak. The optimization of the Pediatric Unit resources for COVID-19 emergency is reported as an example to safely preserve health activity during the pandemic.
